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Bifidobacterium longum BB536

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Related terms
Background
Evidencetable
Tradition
Dosing
Safety
Interactions
Attribution
Bibliography

Related Terms
  • BAA-999, BB536, BB-536, Bifidobacterium longum NCC3001, bifidus milk, bifidus yogurt, BL999, Morinaga Bifidus®, Morinaga Caldus®, oligodeoxynucleotide (ODN) BL07S.

Background
  • Bifidobacterium longum BB536 (BB536) is a Gram-positive bacterium that produces lactic and acetic acids. BB536 is a type of probiotic bacterium. Probiotics are beneficial bacteria (sometimes referred to as "friendly germs").
  • The supposed health benefits of probiotics and BB536 include maintaining the health of the intestinal tract and the immune system and protecting against infection.
  • At this time, research in support of the use of BB536 for allergic disorders is limited mainly to Japanese cedar pollen (JCP). Studies suggest that BB536 and other probiotics may improve bowel function and fecal characteristics. BB536 as part of infant formulas may offer small benefit.
  • Further research is needed to assess the potential benefits of BB536.

Evidence Table

These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. GRADE *


Research suggests BB536 may reduce symptoms associated with Japanese cedar pollen (JCP) allergy. At this time, there is limited information available on other types of allergies. Additional research is needed in this area.

B


The addition of BB536 to the diet, either alone or in combination with other prebiotics, normalized bowel movements and improved moisture, odor, and visual characteristics of feces. BB536 supplementation has also changed bacterial strains in human intestines.

C


A study showed that BB536 reduced the number of vaccinated people who got the flu or a fever. Additional research is needed in this area.

C


Fermented milk with BB536 and other beneficial bacteria may reduce LDL ("bad") cholesterol and HDL ("good") cholesterol. Additional research is needed in this area.

C


BB536 may shorten the time to reach full tube feeding in very-low-birthweight infants. Other studies have suggested that formulas with BB536 do not negatively affect growth or development. Additional research is needed in this area.

C


Milk containing BB536 and other probiotics increased bowel movements and improved moisture, odor, and visual characteristics of feces. BB536 supplementation has also changed bacterial strains in human intestines. Additional research using BB536 alone is needed.

C


Research suggests that BB536 and other probiotics may reduce yeast infections associated with chemotherapy. BB536 has also benefitted fecal bacterial populations. Additional research using BB536 alone is needed.

C
* Key to grades

A: Strong scientific evidence for this use
B: Good scientific evidence for this use
C: Unclear scientific evidence for this use
D: Fair scientific evidence for this use (it may not work)
F: Strong scientific evidence against this use (it likley does not work)


Tradition / Theory

The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.

  • Antibacterial, antiviral, anxiety, bacterial skin infections, cancer, diarrhea, immunomodulation (affects the immune system), inflammation of the small intestine, osteoporosis.

Dosing

Adults (18 years and older)

  • To treat allergies, 5 x 1010 colony-forming units (CFU) per two grams of BB536 have been taken by mouth twice daily for four weeks or 13 weeks. Additionally, 2 x 107 CFU of living BB536 in yogurt have been taken by mouth daily for 14 weeks.
  • To treat constipation, 180-200 milliliters of milk with at least 2 x 109 CFU of BB536 has been taken by mouth daily for up to three weeks. Additionally, 100g of BB536-supplemented yogurt drink (more than 2 x 107 CFU per gram) has been taken by mouth daily for up to three weeks. A two gram sachet of BB536-H (5x1010CFU lyophilized BB536) or BB536-L (2.5x1010CFU lyophilized BB536) powder has been taken by feeding tube once or twice daily for 16 weeks.
  • For flu prevention, 1 x 1011 CFU of BB536 have been taken by mouth daily for three weeks before an influenza vaccine and then for an additional 16 weeks.
  • To treat ulcerative colitis (inflammation of the large intestine), 2-3 x 1011 CFU of BB536 have been taken by mouth daily for 24 weeks.

Children (under 18 years old)

  • There is no proven safe or effective dose for BB536 in children.

Safety

The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.

Allergies

  • Avoid with known allergy or sensitivity to ingredients in probiotic supplements.

Side Effects and Warnings

  • BB536 is categorized by the U.S. Food and Drug Administration (FDA) as Generally Recognized as Safe (GRAS). In studies, adverse effects from BB536 were generally lacking.
  • Use cautiously in people with decreased HDL ("good") cholesterol levels and in pregnant and lactating women.
  • Use cautiously in people taking drugs that alter the immune system.
  • Avoid use in people with a known allergy or sensitivity to ingredients in probiotic supplements.
  • Probiotics may also cause a decrease in HDL ("good") cholesterol levels, cause gas, change bacterial levels in the intestines, increase the frequency of bowel movements and sensations after bowel movements, and stimulate the immune system.

Pregnancy and Breastfeeding

  • There is currently a lack of scientific evidence on the use of BB536 during pregnancy or breastfeeding.

Interactions

Interactions with Drugs

  • BB536 may interact with agents that may affect the immune system, agents that may increase bone strength, antiallergy agents, antianxiety agents, antibiotics, anticancer agents, antidiarrheals, cholesterol-lowering agents, gastrointestinal agents, and laxatives.

Interactions with Herbs and Dietary Supplements

  • BB536 may increase the amount of drowsiness caused by some herbs or supplements.
  • BB536 may interact with antiallergy herbs and supplements, antibacterials, anticancer herbs and supplements, antidiarrheals, cholesterol-lowering herbs and supplements, gastrointestinal agents, herbs and supplements that may affect the immune system, herbs and supplements that may increase bone strength, laxatives, prebiotics, and probiotics.

Attribution
  • This information is based on a systematic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com).

Bibliography
  1. Akatsu, H., Iwabuchi, N., Xiao, J. Z., Matsuyama, Z., Kurihara, R., Okuda, K., Yamamoto, T., and Maruyama, M. Clinical Effects of Probiotic Bifidobacterium longum BB536 on Immune Function and Intestinal Microbiota in Elderly Patients Receiving Enteral Tube Feeding. JPEN J Parenter Enteral Nutr 11-27-2012;
  2. Andrade, S. and Borges, N. Effect of fermented milk containing Lactobacillus acidophilus and Bifidobacterium longum on plasma lipids of women with normal or moderately elevated cholesterol. J Dairy Res. 2009;76(4):469-474.
  3. Chouraqui, J. P., Grathwohl, D., Labaune, J. M., Hascoet, J. M., de, Montgolfier, I, Leclaire, M., Giarre, M., and Steenhout, P. Assessment of the safety, tolerance, and protective effect against diarrhea of infant formulas containing mixtures of probiotics or probiotics and prebiotics in a randomized controlled trial. Am.J Clin.Nutr. 2008;87(5):1365-1373.
  4. Firmansyah, A., Dwipoerwantoro, P. G., Kadim, M., Alatas, S., Conus, N., Lestarina, L., Bouisset, F., and Steenhout, P. Improved growth of toddlers fed a milk containing synbiotics. Asia Pac.J Clin.Nutr. 2011;20(1):69-76.
  5. Gianotti, L., Morelli, L., Galbiati, F., Rocchetti, S., Coppola, S., Beneduce, A., Gilardini, C., Zonenschain, D., Nespoli, A., and Braga, M. A randomized double-blind trial on perioperative administration of probiotics in colorectal cancer patients. World J Gastroenterol. 1-14-2010;16(2):167-175.
  6. Grzeskowiak, L., Gronlund, M. M., Beckmann, C., Salminen, S., von, Berg A., and Isolauri, E. The impact of perinatal probiotic intervention on gut microbiota: double-blind placebo-controlled trials in Finland and Germany. Anaerobe. 2012;18(1):7-13.
  7. Hascoet, J. M., Hubert, C., Rochat, F., Legagneur, H., Gaga, S., Emady-Azar, S., and Steenhout, P. G. Effect of formula composition on the development of infant gut microbiota. J Pediatr.Gastroenterol.Nutr. 2011;52(6):756-762.
  8. Mah, K. W., Chin, V. I., Wong, W. S., Lay, C., Tannock, G. W., Shek, L. P., Aw, M. M., Chua, K. Y., Wong, H. B., Panchalingham, A., and Lee, B. W. Effect of a milk formula containing probiotics on the fecal microbiota of Asian infants at risk of atopic diseases. Pediatr.Res. 2007;62(6):674-679.
  9. Namba, K., Hatano, M., Yaeshima, T., Takase, M., and Suzuki, K. Effects of Bifidobacterium longum BB536 administration on influenza infection, influenza vaccine antibody titer, and cell-mediated immunity in the elderly. Biosci.Biotechnol.Biochem. 2010;74(5):939-945.
  10. Odamaki, T., Xiao, J. Z., Sakamoto, M., Kondo, S., Yaeshima, T., Iwatsuki, K., Togashi, H., Enomoto, T., and Benno, Y. Distribution of different species of the Bacteroides fragilis group in individuals with Japanese cedar pollinosis. Appl.Environ.Microbiol. 2008;74(21):6814-6817.
  11. Rouge, C., Piloquet, H., Butel, M. J., Berger, B., Rochat, F., Ferraris, L., Des, Robert C., Legrand, A., de la Cochetiere, M. F., N'Guyen, J. M., Vodovar, M., Voyer, M., Darmaun, D., and Roze, J. C. Oral supplementation with probiotics in very-low-birth-weight preterm infants: a randomized, double-blind, placebo-controlled trial. Am.J Clin.Nutr. 2009;89(6):1828-1835.
  12. Simakachorn, N., Bibiloni, R., Yimyaem, P., Tongpenyai, Y., Varavithaya, W., Grathwohl, D., Reuteler, G., Maire, J. C., Blum, S., Steenhout, P., Benyacoub, J., and Schiffrin, E. J. Tolerance, safety, and effect on the faecal microbiota of an enteral formula supplemented with pre- and probiotics in critically ill children. J Pediatr.Gastroenterol.Nutr. 2011;53(2):174-181.
  13. Soh, S. E., Aw, M., Gerez, I., Chong, Y. S., Rauff, M., Ng, Y. P., Wong, H. B., Pai, N., Lee, B. W., and Shek, L. P. Probiotic supplementation in the first 6 months of life in at risk Asian infants--effects on eczema and atopic sensitization at the age of 1 year. Clin.Exp.Allergy 2009;39(4):571-578.
  14. Xiao J, Kondol S Odamaki T Miyaji K Yaeshima T Iwatsuki K Togashi H Benno Y. Effect of yogurt containing Bifidobacterium longum BB 536 on the defecation frequency and fecal characteristics of healthy adults: A double-blind cross over study. Japanese Journal of Lactic Acid Bacteria 2007;18(1):31-36.
  15. Xiao, J. Z., Kondo, S., Takahashi, N., Odamaki, T., Iwabuchi, N., Miyaji, K., Iwatsuki, K., and Enomoto, T. Changes in plasma TARC levels during Japanese cedar pollen season and relationships with symptom development. Int.Arch.Allergy Immunol. 2007;144(2):123-127.

Copyright © 2011 Natural Standard (www.naturalstandard.com)


The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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